Key result
Exogenous testosterone therapy was associated with the occurrence of spontaneous coronary artery dissection in a 31-year-old transgender male.
Why the study?
Given known risk factors for SCAD such as hormonal therapies, this case was reported to raise considerations regarding rare unintended consequences of exogenous testosterone therapy.
Case Report (n=1)
Answers are grounded in this paper and cite their sources.
This case highlights a potential rare unintended consequence of exogenous testosterone therapy, specifically spontaneous coronary artery dissection (SCAD).
Spontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndrome, occurring when there is separation of the coronary artery walls by intramural hemorrhage creating a false lumen. This compresses the arterial lumen, compromising the ability of the coronary artery to perfuse the myocardial tissue. Spontaneous coronary artery dissection is usually fatal, with risk factors including pregnancy, young age, and female sex, birth control, and other hormonal therapies.In this case report, we describe the case of a 31-year-old biological female transitioning to male with exogenous testosterone who experienced a SCAD. Given the known risk factors for SCAD, such as pregnancy and exogenous hormone therapy, this case raises additional considerations regarding rare unintended consequences of testosterone therapy.
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Gongolli et al. (2023) conducted a case report in Spontaneous coronary artery dissection (SCAD) (n=1). Exogenous testosterone was evaluated on Spontaneous coronary artery dissection (SCAD). Exogenous testosterone therapy was associated with the occurrence of spontaneous coronary artery dissection in a 31-year-old transgender male.
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