Why the study?
Does the -202 locus polymorphism in the IGFBP3 promoter region affect circulating levels of IGFBP-3?
Does the -202 locus polymorphism in the IGFBP3 promoter region affect circulating levels of IGFBP-3?
A common single nucleotide polymorphism in the IGFBP3 promoter region (-202 A/C) is a major genetic determinant of circulating IGFBP-3 levels.
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The -202 A/C polymorphism determines IGFBP-3 levels; hypothesis-generating for IGF-axis phenotypes and requires prospective validation before clinical consideration.
Deal et al. (2001) studied this question.
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