Key result
Smooth muscle myosin filament sliding on actin is attachment-limited, differing from actin sliding over myosin monomers which is detachment-limited, explaining efficient collective force generation.
This in vitro study demonstrates that smooth muscle myosin filament sliding on actin is attachment-limited, explaining how nonlinear elasticity in motor assemblies leads to efficient collective force generation.
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No immediate clinical implications; extends biophysical models of myosin filament mechanics in smooth muscle.
Haldeman et al. (2014) studied this question. Cross-linked fluorescent rhodamine smooth muscle myosin (XL-Rh-SMM) filaments vs. Actin sliding over myosin monomers was evaluated on ATP dependence of filament velocities and kinetics. Smooth muscle myosin filament sliding on actin is attachment-limited, differing from actin sliding over myosin monomers which is detachment-limited, explaining efficient collective force generation.
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