What question did this study set out to answer?

To evaluate the efficacy and tolerability of a two-week omeprazole regimen combined with one week of amoxycillin and metronidazole for treating Helicobacter pylori-associated peptic ulcer disease.

February 1, 1995Alimentary Pharmacology & Therapeutics

Successful Helicobacter pylori eradication incorporating a one‐week antibiotic regimen

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Authors

NHN HudsonIntensive Care National Audit & Research Centre WBW. G. BrydonWestern General Hospital MEM. A. EastwoodUniversity of Edinburgh

Discussion

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Implication

Clinical trial demonstrates effective Helicobacter pylori clearance in peptic ulcer patients, indicating shorter triple therapy remains viable despite side effect risks.

Key Points

To evaluate the efficacy and tolerability of a two-week omeprazole regimen combined with one week of amoxycillin and metronidazole for treating Helicobacter pylori-associated peptic ulcer disease.
Enrolled 132 consecutive patients with peptic ulcer disease (89 male, 41 female; median age 47 years, IQR 36-58 years).
Administered omeprazole 40 mg daily for 2 weeks, combined with amoxycillin 500 mg t.d.s. and metronidazole 400 mg t.d.s. for the first 7 days.
H. pylori eradication was achieved in 109 of 130 patients, yielding an intention-to-treat rate of 83% (95% CI: 76-89%) and a per-protocol rate of 85% (95% CI: 78-91%).
Treatment was completed by 90% of patients, with adverse effects reported in 41% and treatment discontinuation due to side effects occurring in 3% (4 patients).
One patient developed severe pseudomembranous colitis that required hospital admission.

Cite This Study

Hudson et al. (1995) studied this question.

synapsesocial.com/papers/6a79c1f71b9920df6d891809 https://doi.org/10.1111/j.1365-2036.1995.tb00350.x

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Implication

Clinical trial demonstrates effective Helicobacter pylori clearance in peptic ulcer patients, indicating shorter triple therapy remains viable despite side effect risks.

Successful Helicobacter pylori eradication incorporating a one‐week antibiotic regimen

Discussion

Member takes

Implication

Key Points

Cite This Study

Successful Helicobacter pylori eradication incorporating a one‐week antibiotic regimen

Discussion

Member takes

Implication

Key Points

Cite This Study

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