The inhibitory effect of non-steroidal anti-inflammatory agents on aggregation of red cells in vitro

Aggregation of red cells of rat in saline suspension was induced by gelatin, high molecular weight dextran and fibrinogen. Except chloroquine, non-steroidal anti-inflammatory agents (NAIA) inhibited macromolecule-induced red cell aggregation in vitro. Glucocorticoids failed to inhibit red cell aggregation even in large concentrations. Of many drugs examined, only the NAIA and certain antihistamines, having experimental anti-inflammatory effects proved to be effective inhibitors of gelatin-induced red cell aggregation, in vitro.