Why the study?
Does oxcarbazepine affect the anticoagulant effect of warfarin in healthy male volunteers?
Population
10 healthy male volunteers
Comparison
Oxcarbazepine single dose and multiple dosing… vs Baseline
Design
Other
Follow-up
1 week
Authors
Loading...
No PT change in volunteers; leaves open clinically relevant interactions during chronic warfarin use in patients.
Does oxcarbazepine affect the anticoagulant effect of warfarin in healthy male volunteers?
Oxcarbazepine does not significantly alter the anticoagulant effect of warfarin, suggesting they can be co-administered without major dose adjustments.
Krämer et al. (1992) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: