Key result
LRRC26 knockdown reduced BK channel voltage sensitivity and increased myogenic tone over 40-100 mm Hg intravascular pressures in arterial myocytes.
LRRC26 functions as a BK channel auxiliary γ subunit in arterial myocytes, elevating channel voltage and Ca2+ sensitivity to induce vasodilation.
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May promote arterial vasodilation via BK channels; leaves open therapeutic translation in hypertension.
Evanson et al. (2014) studied this question. LRRC26 knockdown (RNAi) was evaluated on BK channel voltage sensitivity and myogenic tone. LRRC26 knockdown reduced BK channel voltage sensitivity and increased myogenic tone over 40-100 mm Hg intravascular pressures in arterial myocytes.
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