Key result
A 12-week physical exercise program significantly reduced systolic blood pressure in hypertensive older adults with regular (Δ = -6.77 mmHg, p=0.006) and good (Δ = -4.70 mmHg, p=0.013) baseline training status.
Why the study?
Deficiency in nitrite concentration and ACE activity can contribute to hypertension, while physical exercise counteracts these effects, prompting investigation into how 12-week exercise programs affect training status, biomarkers, and blood pressure in hypertensive older adults.
Does a 12-week physical exercise program improve blood pressure, NO2- concentrations, and ACE activity in hypertensive older adults depending on their training status?
Observational (n=95)
No
Does a 12-week physical exercise program improve blood pressure, NO2- concentrations, and ACE activity in hypertensive older adults depending on their training status?
Mean Difference: -6.77
Absolute Event Rate: 125.37% vs 132.15%
p-value: p=0.006
A 12-week physical exercise program significantly reduces systolic blood pressure and modulates ACE activity and NO2- concentrations in hypertensive older adults, provided they achieve a regular or good training status.
Deficiency in nitrite (NO 2 − ) concentration and angiotensin-converting enzyme (ACE) activity can contribute to the high incidence of hypertension. Conversely, physical exercise has been shown to counteract these effects. Thus, the purpose of the study was to verify the effect of physical exercise programs lasting 12 weeks on the training status level (TS), plasma NO 2 − concentrations, ACE activity, and systolic and diastolic blood pressure (SBP / DBP) in hypertensive older adults. After 12 weeks of intervention, participants classified initially with weak TS-level obtained an improvement only in the general functional fitness index (GFFI). Regular TS-level group presented an increase in GFFI and a decrease in ACE activity (34.18 ± 17.82 / 29.73 ± 16.51, p = 0.039 / Δ=-4.44) and SBP (132.15 ± 13.14 / 125.37 ± 12.89, p = 0.006 / Δ=-6.77). Good TS-level group presented improvement in the concentration of NO 2 − (0.134 ± 0.04 / 0.160 ± 0.42, p = 0.001 and Δ = 0.026) and SBP (127.23 ± 11.97 / 122.52 ± 14.55, p = 0.013 and Δ=-4.70). Additionally, the analysis of functional fitness components individually did not influence the BP control variables. These results suggest that changes in the TS (regular or good) provide a positive effect on such variables in hypertensive older adults, however weak TS did not have enough intensity to generate positive changes in BP control variables.
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Silva et al. (2023) conducted an observational in Hypertension (n=95). Physical exercise program vs. Baseline (pre-intervention) was evaluated on Systolic blood pressure (SBP) in the regular training status group (Δ = -6.77, p=0.006). A 12-week physical exercise program significantly reduced systolic blood pressure in hypertensive older adults with regular (Δ = -6.77 mmHg, p=0.006) and good (Δ = -4.70 mmHg, p=0.013) baseline training status.
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