January 1, 2003Circulation JournalOpen Access

Significance of Asymmetric Dimethylarginine (ADMA) Concentrations During Coronary Circulation in Patients With Vasospastic Angina.

View Full Paper

Ask AI

Bookmark

Why the study?

Are elevated ADMA concentrations associated with reduced nitric oxide production in the coronary circulation of patients with vasospastic angina?

Population

32 patients undergoing cardiac catheterization, comprising 16 patients with vasospastic angina with…

Comparison

Measurement of plasma asymmetric… vs Control patients with atypical chest pain and…

Design

Case-control

Authors

THTomoyuki HoriManagement Research Institute TMTaku MatsubaraKobe University TITakaharu IshibashiKanazawa Medical University

Discussion

Member takes

Implication

May link coronary ADMA to reduced NO in VSA; hypothesis-generating and should not yet change practice.

Structured PICO

Are elevated ADMA concentrations associated with reduced nitric oxide production in the coronary circulation of patients with vasospastic angina?

Population

32 patients undergoing cardiac catheterization, comprising 16 patients with vasospastic angina (VSA) (mean age 58, 15 men) with angiographic coronary artery spasm provoked by ergonovine, and 16 control patients (mean age 58, 13 men) with atypical chest pain but no provokable spasm.

Intervention

Measurement of plasma asymmetric dimethylarginine (ADMA) and nitric oxide end-products (NOx) concentrations from the coronary sinus and ostium of the left coronary artery during cardiac catheterization.

Comparator

Control patients with atypical chest pain and angiographically normal or nearly normal coronary arteries without provokable spasm.

Outcome

Coronary sinus-arterial (V-A) differences of NOx and ADMA concentrations.surrogate

Elevated ADMA concentrations in the coronary circulation are associated with reduced nitric oxide production, which may underlie the pathophysiology of coronary vasospasm.

Limitations

NOx and ADMA do not originate solely from the endothelium
Did not measure markers of oxidant stress in the coronary circulation
Unable to determine the contribution of ADMA to oxidative stress

Cite This Study

Hori et al. (2003) studied this question.

synapsesocial.com/papers/6a79e2fe2eb3c7e469f3c3d5 https://doi.org/10.1253/circj.67.305

View Full Paper

Ask AI

Bookmark

Significance of Asymmetric Dimethylarginine (ADMA) Concentrations During Coronary Circulation in Patients With Vasospastic Angina.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Significance of Asymmetric Dimethylarginine (ADMA) Concentrations During Coronary Circulation in Patients With Vasospastic Angina.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider