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October 1, 1988British Journal of Clinical PharmacologyOpen Access

Relationship between the metabolism of antipyrine, hexobarbitone and theophylline in man as assessed by a ‘cocktail’ approach.

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Population

26 healthy volunteers

Design

Other

Authors

JSJ.H.M. SchellensLeiden UniversityJWJH van der WartLeiden UniversityMDMeindert DanhofLeiden University

Discussion

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Implication

Supports cocktail phenotyping of CYP isozymes; leaves open validation before clinical dosing applications.

Structured PICO

P
Population
26 healthy volunteers
I
Intervention
Administration of antipyrine (250 mg) and hexobarbitone (250 mg) in the first experiment, and the addition of theophylline (150 mg) to the combination in the second experiment
O
Outcome
Plasma concentrations of antipyrine, hexobarbitone, and theophylline, urinary excretion of theophylline and antipyrine metabolites, and intrinsic clearance of the substratessurrogate

A 'cocktail' approach of simultaneous administration of antipyrine, hexobarbitone, and theophylline can effectively characterize and correlate the activities of different cytochrome P-450 isozymes in vivo.

Cite This Study

Schellens et al. (1988) studied this question.

synapsesocial.com/papers/6a79e577fbd9051d3b0e0174https://doi.org/10.1111/j.1365-2125.1988.tb03394.x
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