Prolonged low-dosage administration of hexamethylmelamine (NC 13875)

A total of 320 patients were evaluated in a study with prolonged administration of 8 mg/kg hexamethylmelamine. Gastrointestinal and hematopoietic toxicity was increased with this regimen of administration, as compared to the previous study of 21 days on the drug (12 mg/kg) and then 28 days off the drug. The tumor response rate was approximately the same with the most significant responses being seen in carcinoma of the lung and ovary. Further studies using hexamethylmelamine in combination with other agents are anticipated.