Association between periodontal bacteria and degenerative aortic stenosis: a pilot study

Figures

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  Figure 1. Diagram showing patient details and data collection protocols. (A) Subjects were selected according to the criteria shown in the flowchart and (B) data were collected according to the protocols. SAVR: surgical aortic valve replacement, AS: aortic stenosis, Echo: echocardiography, Pg: Porphyromonas gingivalis, Aa: Aggregatibacter actinomycetemcomitans, IgG: immunoglobulin G, hs-CRP: high-sensitivity C-reactive protein.

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  Figure 2. Correlations between the amount of Pg in the saliva and AS parameters. Correlations between Pg in the saliva and (A) AVA, (B) Vmax, (C) mean PG, and (D) DVI. Pg: Porphyromonas gingivalis, AS: aortic stenosis, AVA: aortic valve area, Vmax: maximal velocity, PG: pressure gradient, DVI: Doppler velocity index.

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  Figure 3. Correlations between anti-Pg IgG antibody titer in the serum and AS parameters. Correlations between the anti-Pg IgG antibody titer and (A) AVA, (B) Vmax, (C) mean PG, and (D) DVI. Pg: Porphyromonas gingivalis, IgG: immunoglobulin G, AS: aortic stenosis, AVA: aortic valve area, Vmax: maximal velocity, PG: pressure gradient, DVI: Doppler velocity index.

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  Figure 4. Correlations between the hs-CRP concentration and AS parameters. Correlations between the hs-CRP concentration and (A) AVA, (B) Vmax, (C) mean PG, and (D) DVI. hs-CRP: high-sensitivity C-reactive protein, AS: aortic stenosis, AVA: aortic valve area, Vmax: maximal velocity, PG: pressure gradient, DVI: Doppler velocity index.

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  Figure 5. Correlations between the anti-Pg IgG antibody titer in the serum and AS progression. Correlations between the anti-Pg IgG antibody titer and (A) ΔAVA, (B) ΔVmax, (C) Δmean PG, and (D) ΔDVI. Pg: Porphyromonas gingivalis, IgG: immunoglobulin G, AS: aortic stenosis, AVA: aortic valve area, Vmax: maximal velocity, PG: pressure gradient, DVI: Doppler velocity index.

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  Figure 6. hs-CRP levels according to the progression of degenerative AS. Correlations between the hs-CRP concentration and (A) ΔAVA, (B) ΔVmax, (C) Δmean PG, and (D) ΔDVI. hs-CRP: high-sensitivity C-reactive protein, AS: aortic stenosis, AVA: aortic valve area, Vmax: maximal velocity, PG: pressure gradient, DVI: Doppler velocity index.

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  Figure 7. hs-CRP concentrations between rapid AS progression and non-rapid AS progression groups. hs-CRP: high-sensitivity C-reactive protein, AS: aortic stenosis, AVA: aortic valve area. a)P=0.022