Key result
Current glucocorticoid use was associated with an increased risk of atrial fibrillation or flutter compared with never use (adjusted OR 1.92; 95% CI 1.79-2.06).
Why the study?
Does glucocorticoid use increase the risk of atrial fibrillation or flutter?
Case-Control (n=222,351)
Does glucocorticoid use increase the risk of atrial fibrillation or flutter?
Odds Ratio: 1.92 (95% CI 1.79–2.06)
Absolute Event Rate: 6.4% vs 2.6%
Current glucocorticoid use is associated with a nearly two-fold increased risk of developing atrial fibrillation or flutter, highlighting a significant cardiovascular safety signal for these medications.
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May warrant AF monitoring in glucocorticoid users; leaves open causality and need for confirmatory trials.
Christian Fynbo Christiansen (2009) conducted a case-control in Atrial fibrillation or flutter (n=222,351). Glucocorticoid use vs. Never use was evaluated on Atrial fibrillation or flutter (OR 1.92, 95% CI 1.79-2.06). Current glucocorticoid use was associated with an increased risk of atrial fibrillation or flutter compared with never use (adjusted OR 1.92; 95% CI 1.79-2.06).
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