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December 1, 2019Journal of Thoracic DiseaseOpen Access

Restrictive mitral valve annuloplasty for chronic ischaemic mitral regurgitation: outcomes of flexible versus semi-rigid rings

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Key result

Flexible annuloplasty rings did not significantly differ from semi-rigid rings in 10-year overall survival (53.1% vs 40.0%, P=0.330) or freedom from moderate to severe MR (53.1% vs 53.8%, P=0.725).

Why the study?

Long-term data on the various types of annuloplasty rings used for restrictive mitral annuloplasty in chronic ischaemic mitral regurgitation remain limited.

Does the use of flexible versus semi-rigid annuloplasty rings improve survival and reduce MR recurrence in patients with chronic ischaemic mitral regurgitation undergoing restrictive mitral annuloplasty?

Population

133 patients with CIMR undergoing restrictive mitral annuloplasty

Comparison

Flexible rings vs semi-rigid rings

Design

Single-institution retrospective cohort study

Follow-up

10 years

Authors

PPPhilip Y. K. PangNational Heart Centre SingaporeMHMing Jie HuangTTTeing Ee TanSingHealth

Discussion

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Member takes

Overview

Flexible and semi-rigid rings show similar outcomes in CIMR repair; leaves open optimal ring selection pending randomized trials.

Study Design

Type

Cohort (n=133)

Multicenter

No

Structured PICO

Does the use of flexible versus semi-rigid annuloplasty rings improve survival and reduce MR recurrence in patients with chronic ischaemic mitral regurgitation undergoing restrictive mitral annuloplasty?

P
Population
133 patients (mean age 61.9 years, 22.6% female) with chronic ischaemic mitral regurgitation who underwent restrictive mitral annuloplasty, followed for up to 10 years.
E
Exposure
Flexible annuloplasty rings (n=39)
C
Comparator
Semi-rigid annuloplasty rings (n=94)
O
Outcome
Overall survival and freedom from moderate to severe MR at 10 yearshard clinical

Main Result

Absolute Event Rate: 53.1% vs 40%

p-value: p=0.330

In patients with chronic ischaemic mitral regurgitation, the choice between flexible and semi-rigid annuloplasty rings does not significantly impact 10-year survival or MR recurrence, though semi-rigid rings are associated with greater left ventricular reverse remodelling.

Cite This Study

Pang et al. (2019) conducted a cohort in Chronic ischaemic mitral regurgitation (CIMR) (n=133). Flexible annuloplasty rings vs. Semi-rigid annuloplasty rings was evaluated on Overall survival at 10 years (p=0.330). Flexible annuloplasty rings did not significantly differ from semi-rigid rings in 10-year overall survival (53.1% vs 40.0%, P=0.330) or freedom from moderate to severe MR (53.1% vs 53.8%, P=0.725).

synapsesocial.com/papers/6a79f1b2f48aafa9d7f373fdhttps://doi.org/10.21037/jtd.2019.12.04
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Restrictive Annuloplasty and Coronary Revascularization in Ischemic Mitral Regurgitation Results in Reverse Left Ventricular Remodeling2004 · 353 citations
  2. 2Flexible Versus Nonflexible Mitral Valve Rings for Congestive Heart Failure2006 · 121 citations
  3. 3Preoperative left ventricular dimensions predict reverse remodeling following restrictive mitral annuloplasty in ischemic mitral regurgitation☆2005 · 247 citations
  4. 4A meta-analysis of mitral valve repair versus replacement for ischemic mitral regurgitation.2015 · 29 citations
  5. 5Surgical Treatment of Moderate Ischemic Mitral Regurgitation2014 · 420 citations