Key result
Chronic atrial fibrillation was associated with reduced maximum tension, slower tension activation and relaxation, and decreased passive tension in human atrial myofibrils compared to sinus rhythm.
Why the study?
Does chronic atrial fibrillation alter active and passive force generation in human atrial myofibrils compared to sinus rhythm?
Population
Myofibrils isolated from atrial samples of 31 patients.
Comparison
Chronic atrial fibrillation (cAF) vs Sinus rhythm
Design
Preclinical
Authors
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May link myofilament changes to AF perpetuation; hypothesis-generating and requires prospective confirmation before clinical translation.
Observational (n=31)
Does chronic atrial fibrillation alter active and passive force generation in human atrial myofibrils compared to sinus rhythm?
Chronic atrial fibrillation induces sarcomere-level contractile dysfunction through translational and post-translational changes in myofilament proteins, potentially contributing to arrhythmia perpetuation and atrial dilatation.
Belus et al. (2010) conducted an observational in Chronic atrial fibrillation (n=31). Chronic atrial fibrillation vs. Sinus rhythm was evaluated on Active tension changes and sarcomere length-passive tension relation. Chronic atrial fibrillation was associated with reduced maximum tension, slower tension activation and relaxation, and decreased passive tension in human atrial myofibrils compared to sinus rhythm.
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