The therapy of life-threatening infections is significantly weakened by the global spread of antibiotic resistance. Synthetic exploration of enopeptin type acyldepsipeptide antibiotics revealed a remarkable structure–activity relationship. New compounds with improved in vitro antibiotic activity against Gram-positive pathogens (including multiresistant strains) and in vivo activity in mouse models of lethal infection are described.
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Hinzen et al. (2006) studied this question.
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