Blue mussel (Mytilus edulis) lipid extract ameliorates insulin resistance in diabetic rats by regulating the SphK/So1P signaling pathway

This is the authors' abstract. We don't add key points for this paper.

• Blue mussel lipid extract improved insulin resistance in diabetic rats. • Blue mussel lipid extract improved inflammation in diabetic rats. • Blue mussel lipid extract improved sphingolipid metabolism and insulin signaling pathways in diabetic rats. Studies have shown that blue mussel lipid extract (BMLE) has strong anti-inflammatory activity in both rheumatoid arthritis patients and animal arthritis models. Present study aimed to investigate the effect of BMLE on insulin resistance and its potential mechanisms. Diabetic rats were randomly divided into three groups and received corn oil (CO), fish oil (FO) and BMLE. The results showed that BMLE could effectively reduce Homeostasis model assessment of insulin resistance (HOMA-IR) in diabetic rats. BMLE group showed a significantly lower protein levels of SphK1 and a significantly higher protein levels of SphK2, AKT and P-AKT of liver and skeletal muscle compared with the both CO and FO groups. The liver sphingosine-1 phosphate (So1P) in the BMLE group was significantly higher than in the CO group. In conclusion, the present results demonstrate that BMLE can improve insulin resistance in diabetes rats by reducing inflammatory factors, regulating SphK/So1P pathway and activating insulin signaling pathway.