Key result
Coxsackievirus B1 infection was associated with an increased risk of β-cell autoimmunity, whereas coxsackieviruses B3 and B6 were associated with a reduced risk.
Why the study?
Is Coxsackievirus B1 infection associated with an increased risk of β-cell autoimmunity in children?
Population
549 children from a prospective birth-cohort study, comprising 183 case children testing persistently…
Comparison
Coxsackievirus B1 infection vs Autoantibody-negative matched control children
Design
Case-control
Authors
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Supports enterovirus-specific screening in at-risk children; observational data leave causal role in type 1 diabetes open for prospective confirmation.
Case-Control (n=549)
Is Coxsackievirus B1 infection associated with an increased risk of β-cell autoimmunity in children?
Coxsackievirus B1 infection is associated with an increased risk of β-cell autoimmunity, supporting its role as an environmental trigger for type 1 diabetes.
Laitinen et al. (2013) conducted a case-control in Type 1 diabetes / β-cell autoimmunity (n=549). Coxsackievirus B1 infection vs. Unexposed / matched controls was evaluated on β-cell autoimmunity. Coxsackievirus B1 infection was associated with an increased risk of β-cell autoimmunity, whereas coxsackieviruses B3 and B6 were associated with a reduced risk.