Key result
A 12-week physiological ischemic training program significantly increased peripheral blood VEGF concentrations (81.66 vs 50.5 pg/ml, p<0.05) and improved quality of life in patients with coronary heart disease and heart failure.
Why the study?
Does a 12-week physiological ischemic training program improve quality of life and VEGF levels in patients with coronary heart disease complicated with heart failure?
RCT (n=36)
Single-blind
Random number table method
No
Does a 12-week physiological ischemic training program improve quality of life and VEGF levels in patients with coronary heart disease complicated with heart failure?
Absolute Event Rate: 81.66% vs 50.5%
p-value: p=<0.05
Physiological ischemic training using isometric handgrip exercise is safe and significantly improves quality of life and peripheral VEGF levels in patients with heart failure and coronary heart disease.
Supports adjunctive physiological ischemic training in CHD-HF care; extends ischemic preconditioning evidence to VEGF and QoL endpoints.
Effects of a 12-week physiological ischemic training (PIT) programme on safety of training and quality of life (QOL) in patients with coronary heart disease (CHD) complicated with heart failure were evaluated. A total of 30 patients with CHD complicated with heart failure were randomized to either an intervention group (n=15) or to controls (n=15) after baseline testing. A 12-week, 5 times a week, maximum subjective force group PIT was conducted. Safety of the training was measured with ECG and heart rate and blood pressure, QOL was measured using the Minnesota Living with Heart Failure Questionnaire (MLHFQ) and vascular endothelial growth factor (VEGF) was measured with peripheral blood. VEGF and MLHFQ were improved in the intervention group. The finding of the study shows PIT is safe to patients with CHD complicated with heart failure by improving VEGF of peripheral blood and QOL.
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Gao et al. (2018) conducted an RCT in Coronary heart disease complicated with heart failure (n=36). Physiological ischemic training (PIT) vs. Control (continued living as before with same activity level) was evaluated on Peripheral blood vascular endothelial growth factor (VEGF) concentration at 12 weeks (pg/ml) (p=<0.05). A 12-week physiological ischemic training program significantly increased peripheral blood VEGF concentrations (81.66 vs 50.5 pg/ml, p<0.05) and improved quality of life in patients with coronary heart disease and heart failure.
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