Key result
Decreased right ventricular ejection fraction after cardiac surgery is independently associated with increased ICU length of stay (OR 0.934 per percentage increase in RVEF).
Why the study?
Right ventricular dysfunction is a known risk factor for mortality after cardiac surgery, but its association with ICU morbidity remains largely unknown.
Does decreased right ventricular ejection fraction predict increased ICU morbidity in postoperative cardiac surgery patients?
Cohort (n=1,109)
No
Does decreased right ventricular ejection fraction predict increased ICU morbidity in postoperative cardiac surgery patients?
Odds Ratio: 0.934 (95% CI 0.908–0.961)
p-value: p=<0.001
Impaired right ventricular ejection fraction after cardiac surgery is independently associated with increased ICU morbidity, including prolonged length of stay and mechanical ventilation.
May aid postoperative risk stratification after cardiac surgery; leaves open whether RV interventions shorten ICU stay.
Right ventricular (RV) dysfunction is a known risk factor for increased mortality in cardiac surgery. However, the association between RV performance and ICU morbidity is largely unknown. We performed a single-centre, retrospective study including cardiac surgery patients equipped with a pulmonary artery catheter, enabling continuous right ventricular ejection fraction (RVEF) measurements. Primary endpoint of our study was ICU morbidity (as determined by ICU length of stay, duration of mechanical ventilation, usage of inotropic drugs and fluids, and kidney dysfunction) in relation to RVEF. Patients were divided into three groups according to their RVEF; < 20%, 20–30%, and > 30%. We included 1109 patients. Patients with a RVEF < 20% had a significantly longer stay in ICU, a longer duration of mechanical ventilation, higher fluid balance, a higher incidence of inotropic drug usage, and more increase in postoperative creatinine levels in comparison to the other subgroups. In a multivariate analysis, RVEF was independently associated with increased ICU length of stay (OR 0.934 CI 0.908–0.961, p < 0.001), prolonged duration of mechanical ventilation (OR 0.969, CI 0.942–0.998, p = 0.033), usage of inotropic drugs (OR 0.944, CI 0.917–0.971, p < 0.001), and increase in creatinine (OR 0.962, CI 0.934–0.991, p = 0.011). A decreased RVEF is independently associated with a complicated ICU stay.
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Bootsma et al. (2018) conducted a cohort in Cardiac surgery patients admitted to ICU (n=1,109). Right ventricular ejection fraction (RVEF) was evaluated on Increased ICU length of stay (OR 0.934, 95% CI 0.908-0.961, p=<0.001). Decreased right ventricular ejection fraction after cardiac surgery is independently associated with increased ICU length of stay (OR 0.934 per percentage increase in RVEF).
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