Key result
Hemodialysis was associated with higher anxiety and depression scores and lower rates of high medication adherence (8.9% vs 18.4%; p<0.001) compared to peritoneal dialysis.
Why the study?
Psychiatric disorders like anxiety and depression are highly prevalent in dialysis patients and adversely affect clinical outcomes, but the impact of dialysis modality on mental health and medication adherence needed evaluation.
Does hemodialysis compared to peritoneal dialysis affect mood status and treatment adherence in dialysis patients?
Cross-Sectional (n=192)
Does hemodialysis compared to peritoneal dialysis affect mood status and treatment adherence in dialysis patients?
Absolute Event Rate: 8.9% vs 18.4%
p-value: p=<0.001
Hemodialysis is associated with worse mental health outcomes and lower medication adherence compared to peritoneal dialysis, highlighting the need for tailored interventions.
HD patients show higher anxiety, depression, and lower adherence than PD; hypothesis-generating, prospective studies needed before guiding modality choice.
BACKGROUND: Psychiatric disorders, particularly anxiety and depression, are highly prevalent among dialysis patients and adversely affect clinical outcomes, including adherence to treatment. We aimed to evaluate the impact of dialysis modality on mental health and medication adherence. METHODS: We conducted a cross-sectional study with 192 patients: 89 on hemodialysis (HD) and 103 on peritoneal dialysis (PD). Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS), while medication adherence was evaluated with the Morisky Medication Adherence Scale-8 (MMAS-8). RESULTS: HD patients had higher mean HADS-A (8.03 ± 4.41) and HADS-D (9.47 ± 4.97) scores compared to PD patients (HADS-A: 6.7 ± 3.04; HADS-D: 6.46 ± 3.86, p < 0.01). Regression analysis revealed HD as an independent predictor of anxiety. HD patients had a higher risk of depression than PD patients, although this did not reach statistical significance after adjusting for potential confounders. Medication adherence was higher in PD patients, with 18.4% showing high adherence versus 8.9% in HD patients (p < 0.001). Anxiety and depression were not significantly associated with adherence, although trends suggested lower adherence in patients with worse mental health. CONCLUSION: HD patients experience higher rates of anxiety, depression, and lower medication adherence compared to PD patients. Tailored interventions targeting mental health and adherence could improve clinical outcomes. Future research should explore long-term strategies to optimize care.
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Ada et al. (2025) conducted a cross-sectional in End-stage renal disease requiring dialysis (n=192). Hemodialysis vs. Peritoneal dialysis was evaluated on High medication adherence (p=<0.001). Hemodialysis was associated with higher anxiety and depression scores and lower rates of high medication adherence (8.9% vs 18.4%; p<0.001) compared to peritoneal dialysis.
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