What question did this study set out to answer?

To determine whether fasting increases the binding capacity of the cardiac vascular endothelium for lipoprotein lipase (LPL).

Nutritional regulation of binding sites for lipoprotein lipase in rat heart

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May modulate cardiac lipid uptake in fasting rats; leaves open human relevance and clinical implications.

To determine whether fasting increases the binding capacity of the cardiac vascular endothelium for lipoprotein lipase (LPL).
Injected 125I-labeled bovine LPL into fasted, fed, and refed rats to measure cardiac tracer binding fraction, including pre-injection of unlabeled LPL to test saturability.
Perfused isolated rat hearts at 4°C with a single pass of 125I-labeled LPL to evaluate direct endothelial binding.
Cardiac binding of 125I-LPL was more than twice as high in fasted rats compared with fed rats (4.3% vs. 1.9% of the injected dose), which reversed within 5 hours of refeeding.
Pre-injection of unlabeled LPL reduced 125I-LPL binding, demonstrating that the cardiac binding sites are saturable.
Perfusion of isolated hearts at 4°C confirmed a twofold higher binding of labeled LPL in fasted rats relative to fed controls.

Ruge et al. (2000) studied this question.

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