Why the study?
Does transcoronary gene transfer of SERCA2a improve coronary blood flow and reduce cardiomyocyte size in a Type 2 diabetic rat model?
Population
Otsuka Long-Evans Tokushima fatty rat model of Type 2 diabetes mellitus characterized by diastolic dysfunction
Comparison
Transcoronary gene transfer of SERCA2a via… vs Adenovirus carrying beta-galactosidase gene and…
Design
Preclinical
Follow-up
3 days after infection
Authors
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May improve perfusion and hypertrophy in diabetic rat models; extends preclinical SERCA2a data but leaves open human translation.
Does transcoronary gene transfer of SERCA2a improve coronary blood flow and reduce cardiomyocyte size in a Type 2 diabetic rat model?
In a Type 2 diabetic rat model with diastolic dysfunction, SERCA2a gene transfer increases coronary blood flow and reduces cardiomyocyte hypertrophy without affecting collagen production.
Sakata et al. (2006) studied this question.
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