Key result
Frailty was an independent predictor of in-hospital adverse events in elderly patients with heart failure and reduced ejection fraction, increasing the odds by more than twofold compared to pre-frailty (OR 2.379).
Why the study?
The association between frailty and in-hospital outcomes in elderly patients with HFrEF remains unknown.
Does frailty increase the risk of in-hospital adverse events in elderly patients with HFrEF compared to pre-frailty?
Cohort (n=252)
No
Does frailty increase the risk of in-hospital adverse events in elderly patients with HFrEF compared to pre-frailty?
Odds Ratio: 2.379 (95% CI 1.196–4.733)
p-value: p=0.014
Frailty is highly prevalent in elderly patients with HFrEF and serves as an independent predictor of adverse in-hospital outcomes.
May aid in-hospital risk stratification in elderly HFrEF; leaves open clinical utility and need for prospective validation.
BACKGROUND: Frailty is prevalent in elderly patients with cardiovascular diseases. However, the association between frailty and in-hospital outcomes for elderly patients with heart failure and reduced ejection (HFrEF) remains unknown. AIM: To evaluate the predictive efficacy of frailty, compared with pre-frailty, for adverse events in these patients. METHODS: Elderly patients (≥ 60 years) with HFrEF were assessed. Frailty was evaluated with the Fried phenotype criteria, and physical performance was evaluated based on handgrip strength and the short physical performance battery (SPPB). The composite incidence of adverse events, including all-cause death, multiple organ failure, cardiac shock, and malignant arrhythmia, during hospitalization was recorded. RESULTS: all < 0.05). CONCLUSION: Frailty may be associated with poor in-hospital outcomes for elderly patients with HFrEF. The influence of frailty on long-term prognosis in these patients deserves further investigation.
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Kang et al. (2021) conducted a cohort in Heart failure with reduced ejection fraction (HFrEF) (n=252). Frailty vs. Pre-frailty was evaluated on In-hospital adverse events (composite of all-cause death, multiple organ failure, cardiac shock, and malignant arrhythmia) (OR 2.379, 95% CI 1.196-4.733, p=0.014). Frailty was an independent predictor of in-hospital adverse events in elderly patients with heart failure and reduced ejection fraction, increasing the odds by more than twofold compared to pre-frailty (OR 2.379).
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