Key result
Surgical trials comprise only ~15% of published RCTs and require collaborative, alternative designs.
This narrative review discusses the methodological challenges of conducting randomized controlled trials in surgery, particularly in developing nations, and advocates for leveraging digital platforms, global collaborative networks, and alternative observational study designs.
Answers are grounded in this paper and cite their sources.
Study underrepresentation in surgery warrants cautious clinical decision-making; leaves open the promise of digital collaboration and alternative designs.
Department and Institution to which work should be attributed: Department of Surgical Gastroenterology and Liver Transplant, Sir Ganga Ram Hospital, New Delhi Category in which manuscript is being submitted: Review Article Undertakings: 1. The paper is not based on any previous communication to a society or meeting. 2. There are no conflict of interest involved. 3. This is a review article and hence has no data of its own. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article Published online ■ ■ *Corresponding author. Address: SGRH: Sir Ganga Ram Hospital, New Delhi, Select One, India. E-mail address: [email protected] (T. P. Ramchurn). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
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Ramchurn et al. (2023) conducted a review in Surgical conditions requiring randomized clinical trial evaluation. Surgical randomized clinical trials vs. Non-randomized observational studies and alternative study designs was evaluated.
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