Liquid levothyroxine: questions and answers

Levothyroxine (L-T4) is a drug with a narrow therapeutic range. Even a small change in the dose can lead to its deficiency or overdose. Existing tablet forms of L-T4 with a wide range of dosages ensure the achievement and maintenance of euthyroidism in many patients. At the same time, patients with hypothyroidism are often decompensated. Today, not only tablets are used in the world, but also other forms of L-T4, including gel capsules and liquid form. The presented review discusses the pharmacokinetics, advantages and disadvantages of the different forms of L-T4. Factors affecting the bioavailability of L-T4 drugs are also discussed.