Key result
A combined echocardiographic measurement of dyssynchrony between the septum and left ventricular free wall was independently associated with a reduced risk of death or major cardiovascular hospitalization (HR 0.66).
Why the study?
Do echocardiographic dyssynchrony parameters predict volume response and clinical outcomes in patients undergoing cardiac resynchronization therapy?
Cohort (n=217)
Yes
Do echocardiographic dyssynchrony parameters predict volume response and clinical outcomes in patients undergoing cardiac resynchronization therapy?
Hazard Ratio: 0.66 (95% CI 0.3–0.98)
p-value: p=0.04
Single echocardiographic parameters are insufficient to independently predict CRT response, whereas left bundle branch block remains a strong predictor of both volume response and clinical outcomes.
Authors
No takes yet. Share an insight, caveat, or question.
Should not yet guide CRT selection; leaves open incremental prognostic value of combined dyssynchrony beyond LBBB.
Seo et al. (2011) conducted a cohort in Congestive heart failure (n=217). Combined echocardiographic dyssynchrony (SPWMD >130 ms or Ts >65 ms) vs. Absence of combined echocardiographic dyssynchrony was evaluated on Composite of death from any cause or unplanned hospitalization for a major cardiovascular event (HR 0.66, 95% CI 0.30-0.98, p=0.04). A combined echocardiographic measurement of dyssynchrony between the septum and left ventricular free wall was independently associated with a reduced risk of death or major cardiovascular hospitalization (HR 0.66).
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