Key result
This review addresses the molecular mechanisms pertaining to diabetes-induced heart pathology and the potential for myocardial protection by preconditioning.
This review discusses the molecular mechanisms underlying diabetes-induced heart pathology and the potential protective role of preconditioning.
May guide mechanistic research on preconditioning in diabetic cardiomyopathy; hypothesis-generating and should not yet alter clinical practice.
Both type 1 and type 2 diabetes (insulin-dependent and non-insulin dependent diabetes, respectively) are associated with increased risk for microvascular and macrovascular complications including retinopathy, neuropathy, nephropathy and atherosclerosis. Type 2 diabetes markedly increases the risk for cardiovascular morbidity and mortality, which has major public health implications. In this review, molecular mechanisms pertaining to diabetes-induced heart pathology are addressed.
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Vinokur et al. (2007) conducted a review in Diabetes. Preconditioning was evaluated. This review addresses the molecular mechanisms pertaining to diabetes-induced heart pathology and the potential for myocardial protection by preconditioning.
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