Key result
The ryanodine receptor acts as a sensor for changes in the intracellular environment in skeletal and cardiac muscles, with its activity regulated by factors like cations, nucleotides, and ROS.
Why the study?
Intracellular factors regulate RyR channel activity depending on muscle conditions such as exercise, fatigue, or disease, suggesting RyR may act as an intracellular environment sensor.
The ryanodine receptor functions as a key sensor for intracellular environmental changes in skeletal and cardiac muscles, modulating excitation-contraction coupling.
RyR regulation by condition-dependent factors may underlie muscle dysfunction; leaves open targeted therapies in cardiac disease.
The ryanodine receptor (RyR) is a Ca2+ release channel in the sarcoplasmic reticulum of skeletal and cardiac muscles and plays a key role in excitation–contraction coupling. The activity of the RyR is regulated by the changes in the level of many intracellular factors, such as divalent cations (Ca2+ and Mg2+), nucleotides, associated proteins, and reactive oxygen species. Since these intracellular factors change depending on the condition of the muscle, e.g., exercise, fatigue, or disease states, the RyR channel activity will be altered accordingly. In this review, we describe how the RyR channel is regulated under various conditions and discuss the possibility that the RyR acts as a sensor for changes in the intracellular environments in muscles.
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Kobayashi et al. (2021) conducted a review in Muscle physiology. The ryanodine receptor acts as a sensor for changes in the intracellular environment in skeletal and cardiac muscles, with its activity regulated by factors like cations, nucleotides, and ROS.
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