Key result
Inhibition of locomotor muscle group III/IV afferent feedback elicited increases in stroke volume during submaximal exercise in patients with HFrEF, but not in healthy controls.
Why the study?
It was unknown whether locomotor muscle group III/IV afferents impact central and peripheral responses during submaximal cycling exercise in patients with HFrEF.
Does inhibition of locomotor muscle group III/IV afferent feedback improve stroke volume during submaximal exercise in patients with HFrEF?
Does inhibition of locomotor muscle group III/IV afferent feedback improve stroke volume during submaximal exercise in patients with HFrEF?
Inhibition of locomotor muscle group III/IV afferents increases stroke volume during submaximal exercise in HFrEF patients, highlighting a peripheral mechanism for exercise intolerance.
Answers are grounded in this paper and cite their sources.
May enhance hemodynamics during submaximal exercise in HFrEF; leaves open whether afferent modulation improves capacity or outcomes.
Patients with HFrEF exhibit severe exercise intolerance. One of the primary peripheral mechanisms contributing to exercise intolerance in patients with HFrEF is locomotor muscle group III/IV afferent feedback. However, it is unknown whether these afferents impact the central and peripheral responses during submaximal cycling exercise. Herein, we demonstrate that inhibition of locomotor muscle group III/IV afferent feedback elicited increases in stroke volume during submaximal exercise in HFrEF, but not in healthy controls.
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Smith et al. (2022) studied Heart failure with reduced ejection fraction (HFrEF). Inhibition of locomotor muscle group III/IV afferent feedback vs. Healthy controls was evaluated on Stroke volume during submaximal exercise. Inhibition of locomotor muscle group III/IV afferent feedback elicited increases in stroke volume during submaximal exercise in patients with HFrEF, but not in healthy controls.
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