Key result
The 2017 epidemic of hand, foot, and mouth disease in Osaka City, Japan, involving 6,173 cases, was primarily caused by coxsackievirus A6 strains belonging to genetic groups A3 and A4.
Observational (n=6,173)
The 2017 HFMD epidemic in Osaka City was primarily caused by Coxsackievirus A6, specifically genetic groups A3 and A4, highlighting the role of viral genetic diversity in recurrent outbreaks.
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CV-A6 clade A drove Japan's second-largest HFMD outbreak; leaves open clade-specific surveillance and intervention needs.
The second largest epidemic of hand, foot, and mouth disease since 1982 occurred in 2017, which involved 6,173 cases in Osaka City, Japan. The main causative agent was coxsackievirus A6 (CV-A6). Phylogenetic analysis revealed that the detected CV-A6 strains belonged to genetic groups A3 and A4 in clade A.
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Kanbayashi et al. (2019) conducted an observational in Hand, foot, and mouth disease (HFMD) (n=6,173). Coxsackievirus A6 was evaluated on Causative viral agent and genetic group. The 2017 epidemic of hand, foot, and mouth disease in Osaka City, Japan, involving 6,173 cases, was primarily caused by coxsackievirus A6 strains belonging to genetic groups A3 and A4.
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