A theoretical description of the opening of adrenal cell vesicles during exocytosis (schematically depicted here) is proposed. Single secretion events measured amperometrically can thus be treated with a much better resolution than achievable by patch-clamp techniques. It is concluded that the exocytosis is driven by swelling of the polyelectrolyte gel matrix of the secretory vesicle.
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Amatore et al. (1999) studied this question.