Population
Animals and patients with acute and chronic heart failure, cardiomyopathy, myocardial infarction, diabetes…
Design
Review
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Hypothesis-generating for xanthine oxidase/PARP inhibition in cardiovascular injury; prospective trials needed before clinical adoption.
Oxidative and nitrosative stress, along with downstream pathways like PARP activation, play a crucial role in the pathogenesis of heart failure and cardiomyopathy, presenting potential therapeutic targets.
Ungvári et al. (2005) studied this question.
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