Why the study?
Does carteolol or metoprolol prevent the development of myocardial lesions in a murine model of viral myocarditis and dilated cardiomyopathy?
Population
BALB/c and DBA/2 mice inoculated with encephalomyocarditis virus, n=206 total across acute, subacute, and…
Comparison
Carteolol or metoprolol administered starting on… vs Distilled water (control).
Design
Preclinical
Follow-up
up to 104 days
Authors
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Carteolol may attenuate remodeling in murine viral myocarditis; leaves open differential beta-blocker effects in human disease.
Does carteolol or metoprolol prevent the development of myocardial lesions in a murine model of viral myocarditis and dilated cardiomyopathy?
Carteolol, but not metoprolol, prevented the development of myocardial lesions and adverse remodeling in a murine model of viral myocarditis progressing to dilated cardiomyopathy.
Tominaga et al. (1991) studied this question.
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