April 1, 1985CirculationOpen Access

Treatment of viral myocarditis with ribavirin in an animal preparation.

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Why the study?

Does ribavirin improve survival and reduce myocardial damage in a mouse model of viral myocarditis?

Population

Four-week-old DBA/2 mice inoculated with 10 plaque-forming units of encephalomyocarditis virus

Comparison

Ribavirin administered subcutaneously on days 0… vs Saline injection (n=20)

Design

Preclinical

Follow-up

12 days

Authors

AMAkira MatsumoriKanazawa University HWH Wang WAWalter H. AbelmannHeart Failure / Cardiomyopathy

Discussion

Member takes

Implication

Ribavirin extends survival in murine viral myocarditis; hypothesis-generating and leaves open any role in human disease.

Structured PICO

Does ribavirin improve survival and reduce myocardial damage in a mouse model of viral myocarditis?

Population

Four-week-old DBA/2 mice inoculated with 10 plaque-forming units (pfu) of encephalomyocarditis (EMC) virus (n=60)

Intervention

Ribavirin administered subcutaneously on days 0 to 12 after virus inoculation at doses of 100 mg/kg/day (n=20), 200 mg/kg/day (n=10), or 400 mg/kg/day (n=10)

Comparator

Saline injection (n=20)

Outcome

Survival over 12 dayshard clinical

Ribavirin effectively inhibits myocardial virus replication and reduces inflammatory response and myocardial damage in a murine model of encephalomyocarditis viral myocarditis.

Cite This Study

Matsumori et al. (1985) studied this question.

synapsesocial.com/papers/6a7ae01e0b10e55359899343 https://doi.org/10.1161/01.cir.71.4.834

Topics

Myocarditis

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Treatment of viral myocarditis with ribavirin in an animal preparation.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Treatment of viral myocarditis with ribavirin in an animal preparation.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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