Key result
Women with clinically diagnosed myocarditis were significantly less likely to be admitted to a cardiology ward than men (42.9% vs 66.1%, OR 0.58), despite presenting with more symptoms and comorbidities.
Why the study?
Comprehensive epidemiological data regarding the clinical course of myocarditis and sex differences were lacking.
Observational (n=16,319)
Yes
Odds Ratio: 0.58 (95% CI 0.53–0.62)
Absolute Event Rate: 42.9% vs 66.1%
p-value: p=<0.001
In a nationwide Polish cohort, women with myocarditis were older, had more comorbidities, and were less likely to receive advanced diagnostic procedures or cardiology ward admission compared to men, with younger women experiencing worse prognosis than younger men.
Women received fewer cardiology admissions and diagnostics despite more symptoms/comorbidities; leaves open whether sex-specific protocols could address potential care disparities.
INTRODUCTION: Comprehensive epidemiological data about the course of myocarditis and sex differ-ences are lacking. OBJECTIVES: We aimed to investigate the current differences in the incidence, clinical characteristics, management, and outcomes of men and women with a clinical diagnosis of myocarditis in Poland in the last 10 years. PATIENTS AND METHODS: The nationwide MYO‑PL (Occurrence, Trends, Management, and Outcomes of Patients with Myocarditis in Poland) database identified hospitalization records with a primary diag-nosis of myocarditis following the International Classification of Diseases and Related Health Problems, 10th Revision (ICD‑10), derived from the database of the national health care insurer; ClinicalTrials.gov identifier: NCT04827706. RESULTS: A total of 16 319 patients (4208 [25.8%] women and 12 111 [74.2%] men) aged over 20 years with a hospital‑based clinical diagnosis of myocarditis were included in the study. The women were older than the men (median age, 54 (36-70) and 35 (28-47) years, respectively). The incidence of myocarditis was age-, sex-, and season‑dependent. The incidence rate of myocarditis increased over time only in men. Although women were more symptomatic and demonstrated more comorbidities than men, they were less likely to be admitted to a cardiology ward or undergo diagnostic tests. Regardless of the age and sex, the patients with myocarditis had a poorer prognosis than the general population. The women aged 21-40 years had a poorer prognosis than the men of the same age. CONCLUSIONS: The incidence of myocarditis was age-, sex-, and season‑dependent. Significant improve-ment is required in the management of myocarditis, including the initial diagnostic process, as well as short-and long‑term therapy, particularly in women.
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Ozierański et al. (2022) conducted an observational in Myocarditis (n=16,319). Female sex vs. Male sex was evaluated on Admission to a cardiology unit (OR 0.58, 95% CI 0.53-0.62, p=<0.001). Women with clinically diagnosed myocarditis were significantly less likely to be admitted to a cardiology ward than men (42.9% vs 66.1%, OR 0.58), despite presenting with more symptoms and comorbidities.
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