Key result
Bidomain tissue simulations using a parsimonious ionic current model successfully reproduced the distinctive dip in the anodal strength-interval curve.
Population
Computational model of cardiac tissue (bidomain tissue with a parsimonious ionic current model)
Design
Preclinical
Authors
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Parsimonious model reproduces anodal SI curve dip; leaves open experimental validation of identified mechanisms in cardiac tissue.
A simplified ionic current model in bidomain tissue successfully reproduces the anodal dip in the cardiac strength-interval curve, clarifying the necessary physiological conditions for this phenomenon.
Galappaththige et al. (2017) studied Cardiac tissue electrophysiology. Parsimonious ionic current model was evaluated on Reproduction of the distinctive dip in the anodal strength-interval curve. Bidomain tissue simulations using a parsimonious ionic current model successfully reproduced the distinctive dip in the anodal strength-interval curve.
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