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This Concept article summarizes recent progress in the field of hydrogen-bonding aminocatalysis using proline-derived systems. The aminocatalysts available in the literature are categorized by the incorporated hydrogen-bonding scaffold and its mode of recognition. Both mono- and double-hydrogen-bonding motifs are discussed and examples of their application in asymmetric synthesis are given.
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Albrecht et al. (2013) studied this question.
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