May 26, 1989Science
A G Protein γ Subunit Shares Homology with ras Proteins
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Implication
Research demonstrates genetic similarities in G protein gamma subunits and mammalian ras proteins, suggesting evolutionary connections.
Key Points
- The study aims to identify the homology between G protein gamma subunits and ras proteins.
- Isolated a 71-amino acid protein from bovine brain using a complementary DNA clone.
- Utilized polymerase chain reaction (PCR) to generate a probe for isolation.
- Analyzed the primary sequence and homology of G gamma with T gamma and ras proteins.
- G gamma shows 55% homology to the gamma subunit of transducin (T gamma).
- Divergence identified between T gamma and G gamma indicates a family of gamma subunit genes.
- Functional domains of G gamma exhibit similarity to mammalian ras proteins.
Cite This Study
Gautam et al. (1989) studied this question.