Why the study?
Does non-invasive imaging (ultrasound, MR angiography) reliably assess carotid and vertebral artery disease compared to cerebral angiography?
Does non-invasive imaging (ultrasound, MR angiography) reliably assess carotid and vertebral artery disease compared to cerebral angiography?
Non-invasive imaging modalities like colour duplex ultrasound and MR angiography provide reliable alternatives to invasive cerebral angiography for evaluating carotid and vertebral artery disease.
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Supports non-invasive carotid assessment; leaves open prospective validation versus angiography.
Disease at the carotid bifurcation is most commonly owing to atherosclerosis. Trial data indicate that intervention is beneficial for patients with high grade symptomatic stenoses. Cerebral angiography remains the reference standard, but is invasive. In experienced hands, colour duplex ultrasound is able to reliably grade stenoses and is also able to give information about plaque morphology. A variety of techniques may be used to produce MR angiograms to reliably image the carotid system from the aortic arch to the Circle of Willis Carotid dissection tends to affect a younger age group and is best imaged with a combination of duplex ultrasound and MR angiography.
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Khaw et al. (2001) studied this question.
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