What question did this study set out to answer?

To assess the effect of spinal versus general anaesthesia on the circadian secretion pattern of melatonin in patients undergoing minor knee surgery.

January 1, 2002Acta Anaesthesiologica ScandinavicaOpen Access

The influence of anaesthesia and surgery on the circadian rhythm of melatonin

View Full Paper

Ask AI

Bookmark

Authors

JKJ. KärkeläTampere University Hospital OVOlli VakkuriUniversity of Oulu SKSeppo KaukinenTampere University

Discussion

Member takes

Implication

Randomized trial reveals delayed nocturnal melatonin secretion after knee surgery, indicating acute circadian rhythm disruption regardless of anaesthetic technique.

Key Points

To assess the effect of spinal versus general anaesthesia on the circadian secretion pattern of melatonin in patients undergoing minor knee surgery.
Randomized trial of 20 patients scheduled for minor orthopaedic knee operations allocated to either spinal anaesthesia or general anaesthesia.
Salivary melatonin and nocturnal urinary 6-hydroxymelatonin sulphate concentrations were quantified radioimmunologically during pre- and postoperative periods.
Salivary melatonin secretion was significantly diminished on the first postoperative evening compared with the preoperative baseline (P < 0.001).
Postoperative nocturnal excretion of 6-hydroxymelatonin sulphate exhibited a significant 26% reduction (P < 0.05).
No significant difference in melatonin secretion patterns occurred between the spinal anaesthesia and general anaesthesia cohorts.

Cite This Study

Kärkelä et al. (2002) studied this question.

synapsesocial.com/papers/6a7a2c4a756812e395897489 https://doi.org/10.1034/j.1399-6576.2002.460106.x

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial reveals delayed nocturnal melatonin secretion after knee surgery, indicating acute circadian rhythm disruption regardless of anaesthetic technique.

The influence of anaesthesia and surgery on the circadian rhythm of melatonin

Discussion

Member takes

Implication

Key Points

Cite This Study

The influence of anaesthesia and surgery on the circadian rhythm of melatonin

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider