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April 1, 2002Journal of Biological ChemistryOpen Access

The Mechanism for Regulation of the F-actin Binding Activity of IQGAP1 by Calcium/Calmodulin

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Population

In vitro models and live cells transiently expressing IQGAP1-YFP

Comparison

Calcium/calmodulin vs Absence of calcium/calmodulin or presence of EGTA

Design

Preclinical

Authors

SMScott C. MateerGeorgia Southern UniversityAMAmanda McDanielPulse Biosciences (United States)VNValérie NicolasCentre National de la Recherche Scientifique

Discussion

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Implication

Does not yet alter practice; extends molecular understanding of IQGAP1 but leaves cardiac relevance open.

Structured PICO

P
Population
In vitro models (purified adrenal IQGAP1, recombinant wild type and mutated IQGAP1s) and live cells transiently expressing IQGAP1-YFP
I
Intervention
Calcium/calmodulin (increasing concentrations of calmodulin, elevation of intracellular Ca2+)
C
Comparator
Absence of calcium/calmodulin or presence of EGTA
O
Outcome
Binding of IQGAP1 to F-actin and cellular localization of IQGAP1-YFPsurrogate

This basic science study elucidates the molecular mechanism by which calcium and calmodulin negatively regulate the binding of IQGAP1 to F-actin.

Cite This Study

Mateer et al. (2002) studied this question.

synapsesocial.com/papers/6a7a2e80dd2e05b79c3210cchttps://doi.org/10.1074/jbc.m109535200
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sequential Assembly of Myosin II, an IQGAP-like Protein, and Filamentous Actin to a Ring Structure Involved in Budding Yeast Cytokinesis1998 · 380 citations
  2. 2Identification of IQGAP as a Putative Target for the Small GTPases, Cdc42 and Rac11996 · 311 citations
  3. 3Role of IQGAP1, a Target of the Small GTPases Cdc42 and Rac1, in Regulation of E-Cadherin- Mediated Cell-Cell Adhesion1998 · 505 citations
  4. 4Iqg1p, a Yeast Homologue of the Mammalian IQGAPs, Mediates Cdc42p Effects on the Actin Cytoskeleton1998 · 94 citations