Population
Rat mesenteric small arteries
Comparison
Changes in intracellular pH induced with NH4Cl… vs Resting vessels and different modes of activation
Design
Preclinical
Authors
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These pH effects on vascular tone in animal vessels warrant clinical caution; leaves open relevance to human vasoregulation pending in vivo validation.
Acute intracellular acidification induces vascular tone by releasing a ryanodine-insensitive calcium pool or affecting transmembrane calcium flux independently of membrane potential.
Jensen et al. (1993) studied this question.
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