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January 21, 2014Science Signaling134 citations

The Secreted Protein ANGPTL2 Promotes Metastasis of Osteosarcoma Cells Through Integrin α 5 β 1 , p38 MAPK, and Matrix Metalloproteinases

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Population

Osteosarcoma (OS) cell lines and mouse xenograft models

Comparison

ANGPTL2 expression and signaling vs Normal culture conditions or cells without…

Design

Preclinical

Key result

ANGPTL2 expression in osteosarcoma cells promoted tumor metastasis and decreased animal survival by enhancing tumor cell intravasation mediated by integrin α5β1, p38 MAPK, and MMPs.

Authors

HOHaruki OdagiriTKTsuyoshi KadomatsuMEMotoyoshi Endo

Discussion

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Overview

May support ANGPTL2 targeting in osteosarcoma; animal data leave open clinical translation.

Structured PICO

P
Population
Osteosarcoma (OS) cell lines and mouse xenograft models
E
Exposure
ANGPTL2 expression and signaling
C
Comparator
Normal culture conditions or cells without ANGPTL2 overexpression
O
Outcome
Tumor metastasis and animal survivalsurrogate

Preventing ANGPTL2 signaling stimulated by the tumor microenvironment could inhibit osteosarcoma cell migration and metastasis.

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Cite This Study

Odagiri et al. (2014) studied Osteosarcoma. ANGPTL2 expression vs. Normal culture conditions / low expression was evaluated on Tumor metastasis and animal survival. ANGPTL2 expression in osteosarcoma cells promoted tumor metastasis and decreased animal survival by enhancing tumor cell intravasation mediated by integrin α5β1, p38 MAPK, and MMPs.

synapsesocial.com/papers/6a7a300174c579e25f89206dhttps://doi.org/10.1126/scisignal.2004612
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