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February 17, 2012Cancer ResearchOpen Access

Tumor Cell–Derived Angiopoietin-like Protein ANGPTL2 Is a Critical Driver of Metastasis

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Why the study?

Does tumor cell-derived ANGPTL2 drive metastasis and affect survival in lung cancer?

Population

Patients with lung cancer (surgical resection samples) and xenograft mouse models

Comparison

Attenuating ANGPTL2 expression in tumor cells /… vs Control / lower ANGPTL2 expression

Design

Preclinical

Authors

MEMotoyoshi EndoUniversity of Occupational and Environmental Health JapanMNMasahiro NakanoGifu Prefectural General Medical CenterTKTsuyoshi KadomatsuKumamoto University

Discussion

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Implication

Supports ANGPTL2 blockade to curb metastasis; leaves open clinical translation beyond xenograft models.

Structured PICO

Does tumor cell-derived ANGPTL2 drive metastasis and affect survival in lung cancer?

P
Population
Patients with lung cancer (surgical resection samples) and xenograft mouse models
I
Intervention
Attenuating ANGPTL2 expression in tumor cells (in vivo) / Elevated ANGPTL2 expression (observational)
C
Comparator
Control / lower ANGPTL2 expression
O
Outcome
Metastasis and survival (disease-free survival in humans, overall survival in mice)hard clinical

Tumor cell-derived ANGPTL2 is a critical driver of metastasis, suggesting its blockade could be a therapeutic strategy in cancer.

Cite This Study

Endo et al. (2012) studied this question.

synapsesocial.com/papers/6a7e60ae7ddcd43fa24f9bedhttps://doi.org/10.1158/0008-5472.can-11-3878
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