Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 2012Oncology LettersOpen Access

Angiopoietin-like protein ANGPTL2 gene expression is correlated with lymph node metastasis in lung cancer

View Full Paper
Ask AI
Bookmark
Share

Key result

The tumor-to-normal ratio of ANGPTL2 mRNA levels was significantly higher in lymph node metastasis-positive non-small cell lung cancer cases (2.173) compared with metastasis-negative cases (1.212).

Why the study?

Does ANGPTL2 gene expression correlate with lymph node metastasis and survival in patients with surgically resected NSCLC?

Population

110 surgically resected non-small cell lung cancer (NSCLC) cases, mean age 66.7, 63.6% male, from Japan.

Comparison

Measurement of ANGPTL2 mRNA expression by RT-PCR vs Adjacent normal lung tissues and lymph node…

Design

Cohort

Follow-up

Follow up until August 31, 2011

Authors

HSHidefumi SasakiBroad InstituteASAyumi SuzukiAsahi UniversityMSMasayuki ShitaraToyota Memorial Hospital

Discussion

Loading...

Member takes

Implication

ANGPTL2 ratio associates with lymph node metastasis in resected NSCLC; leaves open survival link and clinical utility pending validation.

Study Design

Type

Observational (n=110)

Multicenter

No

Structured PICO

Does ANGPTL2 gene expression correlate with lymph node metastasis and survival in patients with surgically resected NSCLC?

P
Population
110 surgically treated patients with non-small cell lung cancer from a single center in Japan, evaluated for ANGPTL2 mRNA expression.
E
Exposure
Measurement of ANGPTL2 mRNA expression by RT-PCR
C
Comparator
Adjacent normal lung tissues and lymph node metastasis-negative cases
O
Outcome
Correlation of ANGPTL2 mRNA expression with lymph node metastasissurrogate

Main Result

Absolute Event Rate: 2.173% vs 1.212%

p-value: p=0.0464

ANGPTL2 mRNA expression is significantly elevated in NSCLC with lymph node metastasis, suggesting it may play a role in the metastatic process, though it did not correlate with overall survival.

Limitations

  • The availability of tumor samples in the cohort was limited.
  • The majority of patients with advanced stage NSCLC had only small tissue samples, leaving limited residual samples for molecular diagnosis.
  • The result of RT-PCR was validated in a limited number of patients.
  • Limited availability of tumor samples for qPCR in advanced stage NSCLC
  • Small sample size for validation

Cite This Study

Sasaki et al. (2012) conducted an observational in Non-small cell lung cancer (NSCLC) (n=110). Lymph node metastasis vs. No lymph node metastasis was evaluated on Tumor/normal (T/N) ratio of ANGPTL2/β-actin mRNA levels (p=0.0464). The tumor-to-normal ratio of ANGPTL2 mRNA levels was significantly higher in lymph node metastasis-positive non-small cell lung cancer cases (2.173) compared with metastasis-negative cases (1.212).

synapsesocial.com/papers/6a930d86e94b7197b64aa71chttps://doi.org/10.3892/ol.2012.924
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tumor Cell–Derived Angiopoietin-like Protein ANGPTL2 Is a Critical Driver of Metastasis2012 · 143 citations
  2. 2Frequent Inactivation of a Putative Tumor Suppressor, Angiopoietin-Like Protein 2, in Ovarian Cancer2008 · 54 citations
  3. 3Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases2010 · 152 citations
  4. 4Macrophage-Derived Angiopoietin-Like Protein 2 Accelerates Development of Abdominal Aortic Aneurysm2012 · 111 citations
  5. 5Angiopoietin-Like 2, a Circadian Gene, Improves Type 2 Diabetes Through Potentiation of Insulin Sensitivity in Mice Adipocytes2011 · 43 citations