Key result
ANGPTL2 expression was elevated in HCC tissues and its overexpression promoted HCC cell migration, invasion, and intrahepatic and distal pulmonary metastasis in vitro and in vivo.
Why the study?
Does ANGPTL2 promote migration, invasion, and metastasis in hepatocellular carcinoma?
Population
Human hepatocellular carcinoma tissues and matched noncancerous liver tissues, HCC cell lines, and xenograft…
Comparison
Overexpression or knockdown of ANGPTL2 vs Control
Design
Preclinical
Authors
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ANGPTL2 may drive HCC metastasis in models; leaves open its viability as a therapeutic target pending human validation.
Does ANGPTL2 promote migration, invasion, and metastasis in hepatocellular carcinoma?
ANGPTL2 drives human hepatocellular carcinoma metastasis and may serve as a potential therapeutic target.
Gao et al. (2014) studied Hepatocellular carcinoma. ANGPTL2 vs. Matched noncancerous liver tissues / endogenous levels was evaluated on Cell migration, invasion, and metastasis. ANGPTL2 expression was elevated in HCC tissues and its overexpression promoted HCC cell migration, invasion, and intrahepatic and distal pulmonary metastasis in vitro and in vivo.
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