Answers are grounded in this paper and cite their sources.
Drug-excipient interaction/incompatibility is a major concern for drug stability and effectiveness. Assessing the compatibility of excipients is an essential phase in the formulation process for all pharmaceutical dosage forms. Incompatibility can be investigated using a variety of thermal and nonthermal approaches. Infrared spectroscopy can provide insights into potential intermolecular interactions between components by identifying specific vibrational modes that correspond to physico-chemical properties (chemical bonds and their strength) and molecular symmetry of a molecule. This article reviews some of the most relevant studies on Fourier Transform Infrared spectroscopy utilized as a tool for compatibility screening between 2017 and 2024.
No takes yet. Share an insight, caveat, or question.
Bunaciu et al. (2024) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: