Key result
High Definition Oscillometry provided reproducible blood pressure measurements in macaques (intraindividual CV 2.4-10.8%; mean MAP 96.2 mmHg in males) that accurately corresponded to telemetry.
Why the study?
Does High Definition Oscillometry provide accurate and reproducible non-invasive blood pressure measurements compared to telemetry in cynomolgus monkeys?
Does High Definition Oscillometry provide accurate and reproducible non-invasive blood pressure measurements compared to telemetry in cynomolgus monkeys?
High Definition Oscillometry is an accurate and reproducible non-invasive method for blood pressure monitoring in cynomolgus monkeys, offering a viable alternative to invasive telemetry for detecting drug-related cardiovascular changes.
Supports HDO for BP monitoring in macaque models; leaves open translation to other species or clinical use.
BACKGROUND: Current approaches for accurate blood pressure determination rely predominantly on invasive techniques. High Definition Oscillometry (HDO) was evaluated as a potential non-invasive approach for accurate blood pressure recordings in cynomolgus monkeys. METHODS: In conscious animals, systolic, diastolic, mean arterial blood pressure (MAP) and pulse/minute were determined 15 times within approx. 9 minutes per individual. This session was performed during 3 consecutive days. Anaesthesia induced hypotension was controlled simultaneously with HDO and telemetry as reference. RESULTS: Repeated measurements were highly reproducible. After procedural habituation, mean MAP was 96.2 +/- 13.7 mmHg in males and 86.9 +/- 4.3 mmHg in females. Mean intraindividual coefficients of variation ranged between 10.8% and 2.4% depending on the session and parameter. Values determined by HDO corresponded to those reported for invasive techniques. CONCLUSION: Our results demonstrate, using telemetry as reference, the accuracy of HDO-based non-invasive blood pressure measurements in macaques to detect drug-related cardiovascular changes.
No takes yet. Share an insight, caveat, or question.
Schmelting et al. (2009) studied Blood pressure monitoring. High Definition Oscillometry vs. Telemetry was evaluated on Accuracy and reproducibility of blood pressure measurements. High Definition Oscillometry provided reproducible blood pressure measurements in macaques (intraindividual CV 2.4-10.8%; mean MAP 96.2 mmHg in males) that accurately corresponded to telemetry.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: