What question did this study set out to answer?

This research aims to examine the differing effects of stimulating the right and left vagus nerves on the dog's heart rate and conduction.

December 1, 1912The Journal of Experimental MedicineOpen Access

On the Differences in the Effects of Stimulation of the Two Vagus Nerves on Rate and Conduction of the Dog's Heart

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Why the study?

Does stimulation of the left vagus nerve compared to the right vagus nerve differentially affect heart rate and conduction in dogs?

Population

Dogs of medium size, weighing usually from 5 to 7 kilos (a few 10 to 12 kilos), anesthetized with ether.

Comparison

Electrical stimulation of the left vagus nerve vs Electrical stimulation of the right vagus nerve

Design

Preclinical

Authors

ACAlfred E. CohnUniversity College Hospital

Discussion

Member takes

Implication

May inform selective vagal neuromodulation; leaves open translation from canine models to human arrhythmias.

Key Points

This research aims to examine the differing effects of stimulating the right and left vagus nerves on the dog's heart rate and conduction.
Conducted experiments on dogs stimulating the right and left vagus nerves.
Analyzed heart rate, conduction times, and the occurrence of ectopic contractions.
Observed variations in responses among different dogs.
Stimulation of the right vagus nerve typically causes arrest of all heart chambers.
Left vagus nerve stimulation results in a moderate negative chronotropic effect on auricles, with varying degrees of conduction impact.
Ectopic ventricular contractions can occur following stimulation, with timing influenced by ventricular muscle irritability.

Structured PICO

Does stimulation of the left vagus nerve compared to the right vagus nerve differentially affect heart rate and conduction in dogs?

Population

Dogs of medium size, weighing usually from 5 to 7 kilos (a few 10 to 12 kilos), anesthetized with ether.

Intervention

Electrical stimulation of the left vagus nerve

Comparator

Electrical stimulation of the right vagus nerve

Outcome

Effects on heart rate and auriculoventricular conduction (e.g., arrest of chambers, chronotropic effect, heart-block)surrogate

This foundational preclinical study demonstrated that in dogs, the right vagus nerve primarily controls sinus node rate while the left vagus nerve primarily regulates atrioventricular conduction.

Cite This Study

Alfred E. Cohn (1912) studied this question.

synapsesocial.com/papers/6a7a36bb1ba4614d7ff3d1b8 https://doi.org/10.1084/jem.16.6.732

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On the Differences in the Effects of Stimulation of the Two Vagus Nerves on Rate and Conduction of the Dog's Heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

On the Differences in the Effects of Stimulation of the Two Vagus Nerves on Rate and Conduction of the Dog's Heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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